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The temperature applied in this study was initially reduced at a programmed rate of 5C/min from 4C to 10C, then at a programmed rate of 40C/min from 10 to 100C and finally at a programmed rate of 20C/min from 100 to 140C

Mechanisms include: Increased oxidative stress Glutathione depletion Mitochondrial toxicity Induction of liver detox enzymes Importantly, GGT can rise even with moderate, socially acceptable alcohol intake , especially in genetically susceptible individuals

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Managing side effects well is the difference between successful treatment and discontinuation